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Formulation and evaluation of gastroretentive microspheres loaded with Repaglinide

Gaurav Pandey , Pradeep Chauhan ,

ONLINE ISSN : 2456-8244


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ABSTRACT

Floating microspheres loaded with Repaglinide were prepared using sodium alginate as the natural polymers and guar gum as the release retardant by ionic gelation method. Sodium hydrogen carbonate was utilized as the gas generating agent to render floating property to the microspheres. The formulation of micropsheres was done at various concentrations of the polymers. The drug entrapment efficiencies for the different formulations were in the range of 69.6 to 81.9 % w/w. The floating capacity increased proportionally with the concentration of guar gum. Formulations F4 (83%) and F3 (81%); exhibited the best floating capacity. The percent swelling for all the formulations ranged from 14.5 to 16.9 %. The formulation F2 (15.3%) and F3 (15.8%) exhibited optimal swelling capacities. The cumulative drug release was observed to be 66.363 %, 61.774 %, 63.061 % and 36.035% in formulation F1, F2, F3 and F4 respectively.

KEYWORDS

Microsphere, Gaur Gum, Ionic Gelation, Repaglinide, Gastroretentive, Half life

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REFERENCES

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