Mucoadhesion is a very important phenomenon that effects the gastrointestinal transition of drug molecules. Retention in gastrointestinal tract for longer duration has been helpful in reducing the dose of drugs by sustained release. The objective of the current investigation was to formulate gastroretentive tablets of amlodipine utilizing the potential of gum moringa as a natural mucoadhesive polymer. Wet granulation method was used for formulating gastroretentive dosage form of amlodipine using blend of xanthan gum and gum moringa to prepare the matrix. The thickness of all formulation was ranged in between 4.8 to 4.9 mm while the hardness of the formulations ranged from 4.1 to 4.4 Kg/cm2. The friability of all formulation was in the range of 0.42% to 0.62% and the weight variation was in the range of 1.8 to 3.1 %. Swelling study was performed on all the formulation for 9 h and was found to be in the range of 2.16 to 5.03. The highest degree of swelling was achieved by F6 that contained highest ratios of gum moringa and xanthan gum. The results lead to conclusion that the formulation F5 and F6 were the best formulation that exhibited the desired sustained release, tablet qualities as well as the swelling properties that are desired by a gastroretentive tablets.

Amlodipine, Hypertension, Gastroretentive, Gum Moringa, Mucoadhesion, Tablet

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