Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been published reporting enhanced anticoagulation and bleeding when patients on long-term warfarin therapy also took Salvia miltiorrhiza (danshen). Allium sativum (garlic) decreased the area under the plasma concentration-time curve (AUC) and maximum plasma concentration of saquinavir, but not ritonavir and paracetamol (acetaminophen), in volunteers. A. sativum increased the clotting time and international normalised ratio of warfarin and caused hypoglycaemia when taken with chlorpropamide. Ginkgo biloba (ginkgo) caused bleeding when combined with warfarin or aspirin (acetylsalicylic acid), raised blood pressure when combined with a thiazide diuretic and even caused coma when combined with trazodone in patients. Panax ginseng (ginseng) reduced the blood concentrations of alcohol (ethanol) and warfarin, and induced mania when used concomitantly with phenelzine, but ginseng increased the efficacy of influenza vaccination. Scutellaria baicalensis (huangqin) ameliorated irinotecan-induced gastrointestinal toxicity in cancer patients.

Introduction, Ayurveda, System of Medicines, Scope, Conclusion

Harro H. GMBH Technology for New Drug Delivery Systems Business brieping; Pharmacogenerics 2003 Hikino H, Kiso Y, Wagner H, Fiebig M. Antihepatotoxic actions of flavonolignans from Silybum marianum fruits. Planta Med 1984;50:248-50. Sowjanya JN, Kumar YK, Das S. Phytosome: A novel entity in herbal delivery system. Int J Pharm Res Dev 2010;2:153-64. Patel J, Patel N. An overview of phytosome as an advanced drug delivery system. Asian J Pharma Sci 2009;4:363-71. Kuntal M, Mukherjee K, Ahamed H. Enhanced therapeutic benefit of Quercitin-phospholipid complex in carbon tetrachloride induced acute liver injury in rats: A comparative study. Iran J Pharmacol Ther 2005;4:84-90. Yue PF, Yuan HL, Li XY, Yang M, Zhu WF. Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complex. Int J Pharm 2010;387:139-46. Naik SR, Panda VS. Hepatoprotective effect of Ginkgoselect Phytosome in rifampicin induced liver injury in rats: evidence of antioxidant activity. Fitoterapia 2008;79:439-45. Ajazuddin, Saraf S. Applications of novel drug delivery system for herbal formulations. Fitoterapia 2010;81:680-9.