An Evaluation of Phytochemicals in Maceration and Infusion Extracts of Cyperus rotundus Linn Leaves in Two Different Solvents
Neelam Singh, Madhulika Singh
ONLINE ISSN : 2456-8244ABSTRACT
The objective of the study to evaluate the hepatoprotective effect of ethanolic extract of
Curcuma caesia rhizomes in Wistar rats on paracetamol induced liver. Albino wistar rats were
separated into five groups (n=6). Ethanolic extract of Curcuma caesia rhizomes was prepared
and evaluated for its hepatoprotective efficacy against paracetamol (PCM) (2g/kg p.o.)
induced hepatotoxicity in rats. Silymarin (100mg/kg p.o.) was used as standard. Levels of
Serum glutamic pyruvate transaminase (SGPT), Serum glutamic oxaloacetic transaminase
(SGOT), alkaline phosphatase (ALP), and total protein was evaluated along with
histopathological investigation in various experimental groups of rats. Present study
suggested thatthe protective effect of ethanolic extract of Curcuma caesia against paracetamol
induced hepatic damage.
KEYWORDS
Cyperus rotundus, Phytochemicals, Infusion, Maceration
DOI
REFERENCES
Anonymous (2001). The Wealth of India: A
Dictionary of Indian Raw Materials Boulos L and El-Hadidi MN (1984). The
Weed Flora of Egypt. Cairo: (1984). The
American University in Cairo Press. p.58.
Elezabeth DV and Arumugam S (2013). Study
of the Phytochemical Analysis and Antimicrobial
Activity of Cyperus rotundus Leaves. International J
Current Biotechnol 1(8): 5-8.
Elezabeth DV and Arumugam S (2014).
Phytochemical Screening of the Various Extracts
of Cyperus rotundus. L. American J Pharmtech 4(3):
545-553.
Harborne JB (1983). Phytochemical methods; A
guide to modern Techniques of plant analysis. 3rd
edition Chapman and Hall; New York.
Jeong SJ, Miyamoto T, Inagaki M, Kim YC,
and Higuchi R (2000). Rotundines A-C, Three
Novel Sesquiterpene Alkaloids from Cyperus
rotundus. J Nat Prod 63: 673-675.
Khan S, Choi RJ, Lee DU and Kim YS (2011).
Sesquiterpene Derivatives isolated from Cyperus
rotundus L. inflammatory signaling mediated by
NFxB. Natural Product Sciences 17(3): 250-255.
Khandelwal KR (1997). Practical
Pharmacognosy; Techniques and experiments,
first Edition, Nirali Publication, Pune; p 146
Lansdown RV and JuffeBignoli D (2013).
Cyperus rodundus. The IUCN Red List of
Threatened Species 2013: e.T158183A68258847.
www.iucnredlist.org/details/158183/0
Muthu K, Hema M, Nagaraj S and
Rengasamy R (2014). In-vitro antibacterial
potential, Phytochemical characterization of
Cyperus rotundus flower extract. Internat J Nat Prod
Res 4(1): 6-8.
Rai PK, Kumar R, Malhotra Y, Sharma D and
Karthiyagini T (2010). Standardization and
Preliminary Phytochemical Investigation on
Cyperus rotundus Linn Rhizome. Internat J Res
Ayurveda and Pharmacy 1(2): 536-542.
Kilani-Jaziri S, Bhouri W, Skandrani I,
Limem I, Chekir-Ghedira L and Ghedira K
(2011). Phytochemical, Antimicrobial,
Antioxidant and Antigenotoxic Potentials of
Cyperus rotundus Extracts. South African J Botany 77:
767–776.
Sharma SK and Singh AP (2011).
Morphological, Microscopical and PhysicoChemical Investigations on the Rhizomes of
Cyperus rotundus Linn. Res J Pharmaceutical, Biological
Chem Sci 2(3): 798-806.
Singh N, Pandey BR, Verma P, Bhalla M and
Gilca M (2012). Phyto-Pharmacotherapeutics of
Cyperus rotundus Linn.(Motha): An Overview. Indian
J Natural Products Resources 3(4): 467-476.
Sivapalan SR (2013). Medicinal Uses and
Pharmacological Activities of Cyperus rotundus
Linn. – A Review. Internat J Scientific Research
Publication 3(5): 01-08.
Sivapalan SR and Jeyadevan P. (2012).
Physico-Chemical AndPhyto-Chemical Study of
Rhizome of Cyperus rotundusLinn. Internat J
Pharmacol Pharmaceutical Technol 2(1): 42-46.
Sofowora A (1993). Medicinal Plants and
Traditional medicines in Africa. John Wily and
Sons New York; p 6
Sreenu P, Samatha T, Gandhi N and Naik AS
(2014). Phytochemical Analysis of Root, Stem
and Leaf Extracts in Rubia cordifolia L. an
Important Medicinal Plant. World J Pharm and
Pharmaceutical Sci 3 (10): 826-838.
Vershaeve L, Kestens J, Tylor E and Maes A
(2004). Investigation of the Antimutagenic
Effects of Selected Northeast Medicinal Plants
Extracts. J Essential Oil Res 18: 29-35.