Oral route is the most preferred route of drug delivery for most of the drugs but it presents a considerable challenge for water insoluble drugs. In the present work solid dispersions of cefprozil were prepared in order to improve the water solubility and thereby its bioavailabilty. The solid dispersions were prepared using mannitol and PEG-6000 as the solubility enhancing agent. The solid dispersion was formulated as tablet and the disintegration and dissolution study were performed. The result revealed increased dissolution of cefprozil and improved bioavailability.

Cefprozil, solid dispersion, PEG-6000, solubility enhancement, mannitol

Akiladevi D, Shanmugapandiyan P, Jebasing D (2011) J. Pharm. Sci. 3 (1): 188-191 Ford JL (1986) Acta Helv. 61: 69-88 Mogal SA, Gurjar PN, Yamgar DS, Kamod AC (2012) Der Pharmacia Lettre 4 (5): 1574-1586 Rajeshwari S, Bhanu K, Panda S, Swain RP, Ramana Murthy KV, Kudamala S (2016) J. Chem. Pharm. Res. 8 (4): 1218-1228 Sangeetha E, Rao VU, Sudhakar M, Manisha S (2015) Am. J. Advanced Drug Del. 3 (6): 308-316 Varalakshmi TSNS, Ch. Siva Ramesh, Jyothi I, Jyothi Y, Bharathi G, Chinni Babu P (2015) J. Pharm. Res. 9 (2): 139-144