Estimation of Diacerein using hydrotropic agent and dye drug reaction
Kailashpati Pandey*, Prabhat Jain, Brijeshkunvar Mishra
ONLINE ISSN : 2456-8244ABSTRACT
This study was designed to develop and validate hydrotropic agent and dye drug reaction
methods for estimation of diacerein in capsule formulation. Hydrotropic solubilization is a
technique used to increase the aqueous solubility of poorly water-soluble drugs and the
present study was aimed at developing a hydrotropic technique to increase the solubility of
diacerein. The analysis of tablets indicated good correlation between the amounts estimated
and label claim. The study results indicate good sensitivity of the proposed method. The
results of analysis were validated statistically and by recovery studies. The developed
methods were validated according to ICH guidelines and values of accuracy, precision and
other statistical analysis were found to be in good accordance with the prescribed values.
Thus the proposed method was found to be simple, environmentally friendly, accurate and
cost effective and can be successfully employed in routine analysis of diacerein in capsule.
KEYWORDS
Hydrotropic Solubilizing Agents, Diacerein, Dye Drug Reaction, ICH, validation
DOI
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