The objective of this study was  to evaluate the anti-inflammatory activity of active fractions of Alangium salvifolium leaf extract.From results, it has been inferred that the methanol and aqueous extracts of Alangium salvifolium contain the maximum number of phytoconstituents like alkaloids, glycosides, carbohydrates, flavonoids, tannins and polyphenol. While the alkaloids were absent in aqueous extracts of Alangium salvifolium. Based on the qualitative chemical test, it has been observed that chemically therapeutic compounds were present in sufficient amounts in methanolic and aqueous extracts of Alangium salvifolium. By the help of column chromatography the bioactive fractions were isolated which might be responsible for the therapeutic activity. The eight fractions (F1 to F8) were isolated from the methanol extract of Alangium salvifolium. The F6 and F7 indicate the presence of phenolic compounds and flavonoids. It is scientifically documented that flavonoid molecules possess anti-inflammatory activity on various animal models of inflammation. The isolated compound namely F6 and F7 exhibited anti-inflammatory effect on carrageenan-induced paw oedema. The F6 isolated from Alangium salvifolium produces maximum anti-inflammatory effect compared to F7. This study confirmed that flavonoid fraction obtained from Alangium salvifolium leaves extract are responsible for its anti inflammatory activity and the effects observed are attributable due to the presence of flavonoids in the plant.

Alangium salvifolium, anti-inflammatory, extract, column chromatography, flavonoids

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