The objective of the present investigation was to evaluate the wound healing action of Delonix regia leaf extract in rats. Successive solvent extraction of the leaves of Delonix regia was perfomed using soxhlet method and the extraction abilities of different solvents for recovering extractable components from leaves followed the order: methanol>ethylacetate>water>pet ether. The findings of preliminary phytochemical screening suggest the presence of alkaloids, saponins, phenolics, tannins, terpenoids, sterols, and flavonoids in the leaf of the plant. The acute toxicity study reveals a LD₅₀ of more than 2000 mg/Kg for tannin rich ethyl acetate extract of the plant. The ethyl acetate extract of Delonix regia leaves were evaluated for the in vivo wound healing effect by the excision model. The topical application of 5 % w/w of the Delonix regia resulted in an enhanced and statistically significant (p < 0.001) wound healing activity in vivo. The plant extract exhibited 78.47 ± 5.86 % contraction of wound on the 20^th day whereas only 52.07 ± 5.46 % contraction of wound was found in the control animals.

Wound healing, Delonix regia, flavonoids, extract, in vivo, excision model

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