In the present study niosomes of chrysin were developed 
by thin film hydration technique and characterized. The niosomes 
prepared using varying ratio of surfactant (span 20 and tween 20) 
and cholesterol were evaluated for entrapment efficiency and in 
vitro release. From the result of experimental investigations it was 
observed that using either of the surfactants a 1:2 ratio of surfac-
tant and cholesterol exhibited the maximum entrapment of the 
drug in the core. From the results of the release studies it was 
found that the maximum amount of drug was released from for-
mulations F2 (79.4 %) and F5 (71.8 %) over a period of 18 h at an 
almost steady rate. The higher amount of drug release along with 
the higher entrapment efficiency make the formulations F2 and F5 
containing surfactant to cholesterol ratio of 1:2 the most promis-
ing formulations. The release kinetic was studied using the graph-
ical method and it was found that chrysin released from the nio-
somes following a mixed order kinetics wherein both concentration 
of the drug and erosion of the noisomal matrix played vital role in 
the release of chrysin.

Niosome ,  chrysin ,  half-life ,  cholesterol ,  thin film hydration

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