Oxybenzone is a widely used sunscreen molecule incorporated in various sunscreen lotions and creams. The objective of the present investigation was to formulate oxybenzone as liposomes and convert them into the sunscreen creams or lotions to improve stability and enhance sunscreen efficiency and safety of the molecule. Liposomes of oxybenzone were prepared by dissolving varying amounts of lecithin and drug (2: 0.1, 3.5: 0.1 and 6: 0.1). The liposomes were evaluated for particle size, shape, zeta potential, entrapment efficiency and drug release. The liposomes were formulated as sunscreen cream and evaluated for various parameters and in vitro sunscreen efficacy. A maximum of 80.03% oxybenzone release was observed in the formulation OL3 at the end of 12th h while the lowest was observed for formulation OL5 (65.2%)

Oxybenzone, sunscreen, liposomes, nitroprusside, cream, release

1. Nicholas, J.L., Pathak, M. (1996). Sunscreens: Development, Evaluation and Regulatory Aspects, Cosmetic science technology series. 2nd Edition. CRC press. p. 234-39. 2. Gordan, V.C. (1993). Evaluation du facteur de protection solaire. Parfum. Cosmet. Arom. Paris, 112: 62-65. 3. Mansur, J.S., Breder, MNR., Mansur, MCA., Azulay, RD. (1986). Deterninacao do fator de protecao solar porEspectrofotometria, Bras. Dermatol. Rio de Janeiro. 61: 121-124. 4. Syre, R.M., Agin, P.P., Levee, G.J., Marlowe, E. (1979). Comparison of in-vivo and in-vitro testing of Sunscreening formulas, Photochem. Photobiol. Oxford. 29: 559-566. 5. Afaq, F. and Mukhtar, H. (2006). Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp. Dermatol., 15: 678-684. 6. Farhangi M, Dadshzadeh S, Bolourchian N (2017). Biodegradable Gelatin Microspheres as Controlled Release Intraarticular Delivery System: The Effect of Formulation Variables. Indian J Pharm Sci. 79(1): 105-112. 7. Shaikh KS, Chellampillai B, Pawar AP (2010). Studies on nonionic surfactant bilayer vesicles of ciclopirox olamine. Drug Dev Ind Pharmacy. 36(8): 946-953. 8. Rekha U, Manjula BP (2011). Formulation and evaluation of microsponges for topical drug delivery of Mometasone furoate. Internat J Pharmacy Pharm Sci. 3(4):133-137. 9. Panda P, Ghosh A (2010). Formulation and Evaluation of Topical Dosage Form of Eupatorium Odoratum Linn and Their Wound Healing Activity. Internat J Pharm BioSci. 1(2): 201-203. 10. Purushothamrao K, Khaliq K, Sagare P, Patil SK, Kharat SS, Alpana.K (2010). Formulation and evaluation of vanishing cream for scalp psoriasis. Internat J Pharm Sci Tech. 4(1): 33- 41. 11. Kaidbey KH, Kligman AM (1978). Laboratory methods for appraising the efficacy of sunscreens. J Soc Cosmet Chem. 29: 525–536.