The objective of the current investigation was to develop invasomes loaded with benzoyl peroxide to improve the stability of benzoyl peroxide as well as to control the release of the same from the formulation for a longer duration. The invasomes were prepared by thin layer hydration method using 1:10 ratio of drug to lecithin, employing varying concentrations of eucalyptus oil and peppermint oil (terpenes). The entrapment efficiency, particle size and percent drug release from the invasomes was evaluated. The average particle size of the formulations ranged from 153.4 to 315.4 nm. The size was found to decrease with the increasing concentration of the terpene. The zeta potential of the invasomal formulations -27 mV to -49 mV. The drug entrapment was found to be between 64.15 to 86.35 %. All the formulations could release benzoyl peroxide for upto 12 hours in the in vitro experiments. The formulation F3 was considered the most efficient formulation with smallest particle size (153.4 nm), a zeta potential of -31.6 mV, entrapment efficiency of 82.24 % and a drug release of 99.88 % at the end of the 12th hour.
Invasome, benzoyl peroxide, permeation, lecithin, release, acne
- https://www.drugbank.ca/drugs/DB09096 assessed on 18/12/2022
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