The objective of the current investigation was to formulate delayed release tablets of esomeprazole that could control the release of the drug thereby reducing its dosing frequency and improving the bioavailability. The objective was accomplished by preparation of the matrix tablets using HPMC, carbopol 934 and Eudragit RLPO as the matrix forming polymers. The angle of repose for all formulations was found to be within the range from 25°16 to 27°22. This indicates that good flow property of powder blend. The bulk density and tapped density values were found to be within the range from 0.48 to 0.57 and 0.54 to 0.66 respectively. The Hausner’s ratio values were found to be within the range from 1.10 to 1.21. Swelling study was performed on all the formulation for 9 h and was found to be in the range of 1.29 to 5.06. Results lead to conclusion that the formulation F6 and F8 were the best formulation that exhibited the desired sustained release, tablet qualities as well as the swelling properties that are desired by a matrix tablet.

Esomeprazole, Ulcer, Matrix tablet, Eudragit, Sustained release,

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