The objective of the current investigation was to formulate matrix tablets of ciprofloxacin with an ability to sustain the release of the drug for a period of 12 h. The objective was accomplished by preparation of the matrix tablets employing wet granulation method for formulating the tablets using HPMC and sodium CMC as the matrix forming polymers. The angle of repose for all formulations was found to be within the range from 25°64’ to 27°54’ indicating good flow property of powder blend. The bulk density and tapped density values were found to be within the range from 0.366 to 0.404 and 0.404 to 0.436 respectively.  The Hausner’s ratio values were found to be within the range from 1.02 to 1.12. The thickness of all formulation was ranged in between 4.1 to 4.2 mm while the hardness of the formulations ranged from 6.1 to 6.6 Kg/cm². The friability of all formulation was in the range of 0.23% to 0.61% and the weight variation was in the range of 1.2 to 4.4 %. Swelling study was performed on all the formulation for 9 h. All formulation was in the range of 2.06 to 6.21.  The highest degree of swelling was achieved by F7.

Ciprofloxacin, sustained release, matrix tablets, swelling, HPMC, CMC

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