Formulation Development and Evaluation of Fast Dissolving Oral Films of Nebivolol
Phoolwati Ahirwar*, Suresh Dhakar, B. K. Dubey
ONLINE ISSN : 2456-8244ABSTRACT
Oral films dissolve rapidly along with drug in mouth and majority of the drug is absorbed through
buccal/oral mucosa in to systemic circulation avoiding first pass metabolism. Hypertension is a major
cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a
fast dissolving film containing Nebivolol which is used in the treatment of hypertension with an
objective to rapid dissolution of drug and absorption which may produce the rapid onset of action
and provides the convenient means of administration to those patient suffering from difficulty in
swallowing such as paediatrics, geriatric and uncooperative mentally ill patients and also improve the
bioavailability of the drug. The fast dissolving oral film were prepared using different polymers like
Sodium starch glycolate, Hydroxy propyl methyl cellulose, Croscarmellose sodium and Tween 80 by
solvent casting method. The fast dissolving oral film evaluated for folding endurance, swelling index,
surface pH, in vitro disintegration time, drug content, drug polymer compatibility (IR Study), and in
vitro drug release. The physical appearance and folding endurance properties were found to be good
and electron microscopy shows that films are clear, colourless with smooth surface without any
scratches. The drug content showed uniform mixing of drug in all prepared fast dissolving films. The
in vitro drug release in optimized formulation F9 was found to be 69.56 % in 5 min. Drug release
obeys the first order kinetics. The prepared films were stable. Hence it can be inferred that the fast
dissolving oral film of nebivolol may produce the rapid action thereby improving bioavailability and
enhance the absorption by avoiding the first pass effect.
KEYWORDS
Fast dissolving oral films, Nebivolol, Sodium starch glycolate, Hydroxy propyl
methyl cellulose, Croscarmellose sodium and Tween 80
DOI
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