The objective of the present work was to formulate gastroretentive floating tablets of fexofenadine for achieving prolonged action. Total six formulations of floating tablets were prepared using direct compression (F1 to F6). The concentration and type of polymeric matrix was varied; HPMC K5 (F1 to F3) and HPMC K16 (F4-F6). All the formulations were subjected to post compression evaluation test and the results indicate that the formulation had hardness of around 5 Kg/cm2, thickness of 5 mm, weight variation in the range of 2.7-3.3 %, friability of less than 1 %, drug content in the range of 97.2 to 98.9 %. The floating lag time of all the formulations was less than 45 sec and the floating duration was more than 12 h.

Floating Tablet, HPMC, Fexofenadine, Sustained Release, Gastroretentive, Bioavailability

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