In the present work newer antioxidants based on qui-
nalzoline nucleus were synthesized and evaluated. The confirma-
tion of the structure of the synthesized compounds was done by 
IR, 1HNMR and mass spectral studies. The antioxidant potential of 
the synthesized compounds was also evaluated and the the data 
reveals IC50 value of 17.4 to 32.6 µg/mL against DPPH radical and 
18.3 to 37.4 µg/mL against hydroxy radical. The compounds 4d & 
4e exhibited the best antioxidant activity against DPPH and HRSA 
assays. The results revealed that higher electron withdrawing po-
tential in the benzene substituent resulted in higher antioxidant 
capacity. On the other hand compound 4a with an aliphatic chain 
exhibited the least antioxidant activity in both the assays. 

Quinazoline ,  microwave  ,  antioxidant ,  DPPH ,  HRSA  

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