The objective of the study to evaluate the hepatoprotective effect of ethanolic extract of Curcuma caesia rhizomes in Wistar rats on paracetamol induced liver. Albino wistar rats were separated into five groups (n=6). Ethanolic extract of Curcuma caesia rhizomes was prepared and evaluated for its hepatoprotective efficacy against paracetamol (PCM) (2g/kg p.o.) induced hepatotoxicity in rats. Silymarin (100mg/kg p.o.) was used as standard. Levels of Serum glutamic pyruvate transaminase (SGPT), Serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP), and total protein was evaluated along with histopathological investigation in various experimental groups of rats. Present study suggested thatthe protective effect of ethanolic extract of Curcuma caesia against paracetamol induced hepatic damage.

Curcuma caesia, Hepatoprotective effect, paracetamol, Histopathological study, cirrhosis

1. Wang S, Nagrath D: Liver Tissue Engineering. Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends 2010, 14: 389. 2. Friedman SL, McQuaid KR, Grendell JH: Current diagnosis & treatment in gastroenterology. New York: Lang Medical Books/McGraw-Hill 2002. 3. O'Connell M, Rushworth S: Curcumin: potential for hepatic fibrosis therapy? Br J Pharmacol 2008, 153 (3): 403-405. 4. Thamizh Selvam N, Venkatakrishnan V, et al. Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistaralbino rats. Ayu 2013, 34: 305-307. 5. Akindele AJ, Ezenwanebe KO, et al. Hepatoprotective and in vivo antioxidant effects of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae). J Ethnopharmacol 2010, 129: 46–52. 6. Kallappa SG and Jambilingappa LK. Evaluation of hepatoprotective activity of aqueous extract of Azadirachta indica (neem) leaves against paracetamol induced hepatotoxicity in albino rats. Pharmacologyonline 2011, 2: 96–108. 7. Sharma PC, Yelne MB et al. Database on Medicinal plants used in Ayurveda. CCRAS 2002, 4: 34-8. 8. World Health Organization. WHO Monographs on selected medicinal plants. Geneva: AITPBS Publications and Distributors 2002, 2: 12-24. 9. OECD. Guideline for Testing of Chemicals-Acute Oral Toxicity-Acute Toxic Class Method. Paris: OECD 2001. 10. Narasimhanaidu K, Rajagopalan R, Varma PS, et al. Comparative Effects of Curcumin and an analogue of Curcumin in Carbon Tetrachloride induced Hepatotoxicity in Rats, Basic and Clinical Pharmacology and Toxicology 2005; 97: 15-21. 11. Somchit MN, Ahmad BA, Somchit N, Sulaiman MR, Noratunlina R. Protective activity of Turmeric (curcuma longa) in Paracetamol induced Hepatotoxicity in Rats. Internat J Pharmacol 2005; 3:252-256. 12. Galighor, AE, Kozloff EN. Essentials of practical microtechnique 2nd edn, Lea and Febiger, NewYork 1976.