The present work was undertaken with an aim to determined the effect of combined extract of Murraya koenigii and Ocimum sanctum.  The extraction yield in the solvent mixture was found to be 39.6 % for Murraya koenigii and 43.7 % for Ocimum sanctum The findings of preliminary phytochemical analysis suggest the presence of alkaloids, saponin glycosides, phenolics, terpenoids, and flavonoids in the leaf of the Murraya koenigii while alkaloids were not found to be present in Ocimum sanctum. The total phenolic content of the hydroalcoholic extracts of M. koenigii and O. sanctum were 38.31±1.7 and 54.27±2.1GAE mg/g, respectively. The phenolic content was highest in the combined extract (MSE:OSE, 1:2) of all the three combinations with total phenolics 63.9±3.8 GAE mg/g. The extracts were individually and in combination (1:1, 1:2 & 2:1) subjected to determination of anti-inflammatory potential by carrageenan induced rat paw edema method using ibuprofen as the standard drug. Ibuprofen at dose of 10 mg/Kg inhibited 69.23% edema after 4h of administration whereas the maximum edema inhibition exhibited by the combined extracts was 52.47% (MKE:OSE, 1:2)  at the end of 4h.

Murraya koenigii, Ocimum sanctum, carrageenan, anti-inflammatory, Ibuprofen, combined extracts

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