Triazines are a widely studied class of compounds having 
various pharmacological activities. In this work, Mannich bases of 
1,2,4-triaizine were synthesized and evaluated for antibacterial 
action. The synthesis was achieved in two simple steps involving 
formation of traizine nucleus and subsequent Mannich base for-
matiom. The compound TZM5 & TZM6 showed the highest antimi-
crobial activities against all of the tested organisms (bacteria). In 
contrast, compound TZM1 showed lower antimicrobial activity 
against all tested microorganisms. 

1,2,4-triazine,  Antibacterial,  Mannich base,  prodrug,  Zone of inhibition 

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