In the present work, cinnamic acid was modified to prepare 
1,2,4-triazole-thiol analogs were synthesized and evaluated for an-
ti-bacterial activity using disc diffusion/cup and plate method. 
Spectral analyses (IR and NMR) of the compounds satisfactorily 
supported the structures of the synthesized compounds. The FT-
IR spectrum of compounds exhibited sharp peaks at 3200-2700 
cm-1 (aliphatic C-H), 1400-1700 cm-1 (aromatic ring) and 2400-
2600 cm-1 (S-H str.), in all compounds while vibrations of NO2 
(1300-1400 cm-1), C-Cl (850-550 cm-1) were also found in the cor-
responding compounds. The 1H NMR spectra exhibit chemical 
shifts at δ 6.5-7.9 (aromatic protons), 1.25-2.56 (CH2) and 0.8 
(CH3) and 8.0-8.4 (=CH) in corresponding compounds. The anti-
bacterial activity of the synthesized compounds was evaluated at 
four different concentrations and the zone of inhibition was meas-
ured against gram negative and gram positive bacteria. Only one 
compound (CT4) was found to contain a significant antibacterial 
action against the tested microorganisms. Also the action was bet-
ter against gram positive bacteria in comparison to the gram nega-
tive bacteria. 

Cinnamic acid ,  1,2,4-triazole ,   antimicrobial ,  disc diffusion ,  synthesis  

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