In the effort to develop new potential molecule for the betterment of the health condition, a few of novel substituted azetidinones were synthesized using microwave assisted method and characterized for antibacterial action. The IR spectra of all the compounds exhibited the stretching vibration peaks due to C-N, C=O, C=N at 1400-1000 cm-1, 1765-1645 cm-1 and 1690-1520 cm-1 (medium) respectively. The other vibrations that appeared in the spectra included those from aromatic C=C and C-H, C-H alkane, C-Cl (4e), CO (4d), C-H (methoxy), C-C (cycobutyl) and C=O (cycobutyl). The 1HNMR spectra obtained displayed the peaks of aliphatic CH and aromatic CH at 2-3.3, and 6.7-7.2 ppm respectively. The mass spectra displayed the molecular ion peak and the isotopic peaks as calculated. The MIC of compounds 4c, 4d, 4e and 4f was found to be 6.25 µg/mL against gram positive bacteria and 12.5 µg/mL against gram negative bacteria. Compounds 4a and 4b exhibited were not found to be not very significant in comparison to the reference drug.

Azetidinone, Microwave, Antibacterial, Minimum inhibitory concentration, Nucleophilic substitution

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